Dr Amandine Marechal
-
Overview
Overview
Biography
I am a biophysicist/biochemist with interests in molecular reaction mechanisms of enzyme catalysis with emphasis on biological energy conversion systems. I am an expert in infrared spectroscopy and its application to protein studies. My main research project is funded by the Medical Research Council U.K. It focuses on the understanding of the proton coupled electron transfer in respiratory cytochrome c oxidases and the way 'supernumerary' subunits or environmental factors influence catalysis.
Highlights
Hartley A.M., Meunier B., Pinotsis N., Maréchal A. (2020) Rcf2 revealed in cryoEM structures of hypoxic isoforms of mature mitochondrial III-IV supercomplexes. Proc. Nat. Acad. Sci. USA 117 (17), 9329-9337
DOI: 10.1073/pnas.1920612117
Maréchal A., Xu J.-Y, Genko N., Hartley A.M., Haraux F., Meunier B., Rich P.R. (2020) A common coupling mechanism for A-type heme-copper oxidases from bacteria to mitochondria. Proc. Nat. Acad. Sci. USA 117 (17), 9349-9355
DOI: 10.1073/pnas.2001572117
Hartley A.M., Lukoyanova N., Zhang Y., Cabrera-Orefice E., Arnold S., Meunier B., Pinotsis N., Maréchal A. (2019) Structure of yeast cytochrome c oxidase in a supercomplex with cytochrome bc1. Nat. Struct. Mol. Biol. 26 (1), 78-83
DOI: 10.1038/s41594-018-0172-z
Web profiles
Administrative responsibilities
- Graduate Committee Member
Honours and awards
- Transition Support Award, Medical Research Council U.K., December 2021
- Career Development Award, Medical Research Council U.K., December 2015
ORCID
0000-0003-3460-3806 -
Research
Research
Research interests
- Mitochondrial respiratory chain
- Supercomplexes
- Cytochrome c oxidase
- FTIR spectroscopy
Research Centres and Institutes
Research projects
Towards the resolution of the full catalytic cycle of cytochrome c oxidase
Cytochrome c oxidase: structure, function and malfunction.
Post doctoral staff
- Dr Thomas Gruhl
-
Supervision and teaching
Supervision and teaching
Supervision
I welcome enquiries from prospective PhD students who are interested in undertaking research in any of my areas of research interest.
Teaching
Teaching modules
- Protein Structure and Function (SCBS078H5)
- Protein Structure and Function (SCBS078H5)
-
Publications
Publications
Article
- Yang, T. and Filippov, I. and Manathunga, L. and Baghai, A. and Marechal, Amandine and Raleigh, D.P. and Zhyvoloup, A. (2024) On the importance of being amidated: analysis of the role of the conserved C-terminal amide of amylin in amyloid formation and cytotoxicity. Biophysical Chemistry 307 (107168), ISSN 0301-4622.
- Mühleip, A. and Kock Flygaard, R. and Baradaran, R. and Haapanen, O. and Gruhl, Thomas and Tobiasson, V. and Marechal, Amandine and Sharma, V. and Amunts, A. (2023) Structural basis of mitochondrial membrane bending by the I–II–III2–IV2 supercomplex. Nature 615, pp. 934-938. ISSN 0028-0836.
- Ing, G. and Hartley, A. and Pinotsis, Nikos and Marechal, Amandine (2022) Cryo-EM structure of a monomeric yeast S. cerevisiae complex IV isolated with maltosides: implications in supercomplex formation. Biochimica et Biophysica Acta (BBA) - Bioenergetics 1863 (7), pp. 148591. ISSN 0005-2728.
- Jordan, S.F. and Ioannou, I. and Rammu, H. and Halpern, A. and Bogart, L.K. and Ahn, M. and Vasiliadou, R. and Christodoulou, J. and Maréchal, Amandine and Lane, N. (2021) Spontaneous assembly of redox-active iron-sulfur clusters at low concentrations of cysteine. Nature Communications 12, pp. 5925. ISSN 2041-1723.
- Marechal, Amandine and Xu, J.-Y. and Genko, N. and Hartley, Andrew and Haraux, F. and Meunier, B. and Rich, P. (2020) A common coupling mechanism for A-type heme-copper oxidases from bacteria to mitochondria. Proceedings of the National Academy of Sciences of the United States of America 117 (17), pp. 9349-9355. ISSN 0027-8424.
- Hartley, Andrew and Meunier, B. and Pinotsis, Nikos and Marechal, Amandine (2020) Rcf2 revealed in cryoEM structures of hypoxic isoforms of mature mitochondrial III-IV supercomplexes. Proceedings of the National Academy of Sciences of the United States of America 117 (17), pp. 9329-9337. ISSN 0027-8424.
- Björck, M.L. and Vilhjámsdóttir, J. and Hartley, Andrew and Meunier, B. and Näsvik Öjemyr, L. and Marechal, Amandine and Brzezinski, P. (2019) Proton-transfer pathways in the mitochondrial S. cerevisiae cytochrome c oxidase. Scientific Reports 9 (1), pp. 20207. ISSN 2045-2322.
- Jordan, S.F. and Rammu, H. and Zheludev, I.N. and Hartley, Andrew and Marechal, Amandine and Lane, N. (2019) Promotion of protocell self-assembly from mixed amphiphiles at the origin of life. Nature Ecology & Evolution ISSN 2397-334X.
- Hartley, Andrew and Lukoyanova, Natalya and Zhang, Y. and Cabrera-Orefice, A. and Arnold, S. and Meunier, B. and Pinotsis, Nikos and Marechal, Amandine (2018) Structure of yeast cytochrome c oxidase in a supercomplex with cytochrome bc1. Nature Structural & Molecular Biology 26, pp. 78-83. ISSN 1545-9993.
- Marechal, Amandine and Hartley, Andrew M. and Warelow, Thomas P. and Meunier, B. and Rich, P.R. (2018) Comparison of redox and ligand binding behaviour of yeast and bovine cytochrome c oxidases using FTIR spectroscopy. Biochimica et Biophysica Acta (BBA) - Bioenergetics 1859 (9), pp. 705-711. ISSN 0005-2728.
- Liu, C. and Cozens, C. and Jaziri, F. and Rozenski, J. and Marechal, Amandine and Dumbre, S. and Pezo, V. and Marliere, P. and Pinheiro, Vitor B. and Groaz, E. and Herdewijn, P. (2018) Phosphonomethyl Oligonucleotides as Backbone-Modified Artificial Genetic Polymers. Journal of the American Chemical Society 140 (21), pp. 6690-6699. ISSN 0002-7863.
- Lang, J. and Marechal, Amandine and Couture, M. and Santolini, J. (2016) Reaction intermediates and molecular mechanism of Peroxynitrite activation by NO synthases. Biophysical Journal 111 (10), pp. 2099-2109. ISSN 0006-3495.
- Oliver, K.V. and Vilasi, A. and Marechal, Amandine and Moochhala, S.H. and Unwin, R.J. and Rich, P.R. (2016) Infrared vibrational spectroscopy: a rapid and novel diagnostic and monitoring tool for cystinuria. Scientific Reports (6), ISSN 2045-2322.
- Oliver, K.V. and Marechal, Amandine and Rich, P.R. (2016) Effects of the hydration state on the mid-infrared spectra of urea and creatinine in relation to urine analyses. Applied Spectroscopy 70 (6), pp. 983-994. ISSN 0003-7028.
External Repositories