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Info
Positions held:
Professor of Mass Spectrometry,
School of Natural Sciences
Supervision and teaching
Supervision and teaching
Supervision
Supervisions within Birkbeck:
1
Doctoral alumni since 2013-14
TANYA PRENTICE
Nature of supervision:
Principal Supervisor,
Apr 2014
Awarded:
2018
Teaching
Teaching modules
Advanced Topics in Human Disease (SCBS081H6) Advanced Topics in Human Disease (SCBS081H6) Biochemical Analysis (SCBS090S7) Biochemical Analysis (SCBS090S7)
Publications
Publications
Article
Levray, Y.S. and Bana, Bianca and Tarr, S.J. and McLaughlin, E.J. and Rossi-Smith, P. and Waltho, A. and Charlton, G.H. and Zenezini Chiozzi, R. and Straton, C.R. and Thalassinos, Kostas and Osborne, Andrew
(2023)
Formation of ER-lumenal intermediates during export of Plasmodium proteins containing transmembrane-like hydrophobic sequences .
PLoS Pathogens
ISSN 1553-7374.
Bagneris, Claire and Senthil Kumar, Swathi and Baratchian, M. and Britt, H. and Tufa, A. and Britt, H. and Thalassinos, Kostas and Collins, M. and Barrett, Tracey
(2022)
Mechanistic insights into the activation of the IKK kinase complex by the Kaposi’s Sarcoma Herpes virus oncoprotein vFLIP .
Journal of Biological Chemistry
298
(6),
pp. 102012.
ISSN 0021-9258.
Modi, T. and Gervais, D. and Smith, S. and Miller, J. and Subramaniam, S. and Thalassinos, Kostas and Shepherd, Adrian J.
(2021)
Characterisation of the UK anthrax vaccine and human immunogenicity .
Human Vaccines & Immunotherapeutics
17
(3),
pp. 747-758.
ISSN 2164-5515.
Scholes, H.M. and Cryar, A. and Kerr, F. and Sutherland, D. and Gethings, L.A. and Vissers, J.P.C. and Lees, J.G. and Orengo, C.A. and Partridge, L. and Thalassinos, Kostas
(2020)
Dynamic changes in the brain protein interaction network correlates with progression of Aβ42 pathology in Drosophila .
Scientific Reports
10
(1),
ISSN 2045-2322.
Eldrid, C. and Ujma, J. and Kalfas, S. and Tomczyk, N. and Giles, K. and Morris, M. and Thalassinos, Konstantinos
(2019)
Gas phase stability of Protein Ions in a Cyclic Ion Mobility Spectrometry Traveling Wave Device .
Analytical Chemistry
91
(12),
pp. 7554-7561.
ISSN 1520-6882.
Gabelica, V. and Shvartsburg, A.A. and Afonso, C. and Barran, P. and Benesch, J.L.P. and Bleiholder, C. and Bowers, M.T. and Bilbao, A. and Bush, M.F. and Campbell, J.L. and Campuzano, I.D.G. and Causon, T. and Clowers, B.H. and Creaser, C.S. and De Pauw, E. and Far, J. and Fernandez-Lima, F. and Fjeldsted, J.C. and Giles, K. and Groessl, M. and Hogan, C. J. and Hann, S. and Kim, H.I. and Kurulugama, R.T. and May, J.C. and McLean, J.A. and Pagel, K. and Richardson, K. and Ridgeway, M.E. and Rosu, F. and Sobott, F. and Thalassinos, Konstantinos and Valentine, S.J. and Wyttenbach, T.
(2019)
Recommendations for reporting ion mobility Mass Spectrometry measurements .
Mass Spectrometry Reviews
ISSN 0277-7037.
Tosi, T. and Hoshiga, F. and Millership, C. and Singh, R. and Eldrid, C. and Patin, D. and Mengin-Lecreulx, D. and Thalassinos, Konstantinos and Freemont, P. and Gründling, A.
(2019)
Inhibition of the Staphylococcus aureus c-di-AMP cyclase DacA by direct interaction with the phosphoglucosamine mutase GlmM .
PLoS Pathogens
15
(1),
pp. e1007537.
ISSN 1553-7374.
James, J.M.B. and Cryar, A. and Thalassinos, Konstantinos
(2019)
Optimization workflow for the analysis of cross-linked peptides using a Quadrupole Time-of-Flight Mass Spectrometer .
Analytical Chemistry
91
(3),
pp. 1808-1814.
ISSN 0003-2700.
Bullock, Joshua M.A. and Sen, N. and Thalassinos, Konstantinos and Topf, Maya
(2018)
Modeling protein complexes using restraints from Crosslinking Mass Spectrometry .
Structure
26
(7),
pp. 1015-1024.e2.
ISSN 0969-2126.
Bullock, Joshua and Thalassinos, Konstantinos and Topf, Maya
(2018)
Jwalk and MNXL web server: model validation using restraints from Crosslinking Mass Spectrometry .
Bioinformatics
34
(20),
pp. 3584-3585.
ISSN 1367-4803.
Blombach, F. and Ausiannikava, D. and Figueiredo, A.M. and Soloviev, Z. and Prentice, T. and Zhang, M. and Zhou, N. and Thalassinos, Konstantinos and Allers, T. and Werner, F.
(2018)
Structural and functional adaptation of Haloferax volcanii TFEα/β .
Nucleic Acids Research
46
(5),
pp. 2308-2320.
ISSN 0305-1048.
Sivalingam, G.N. and Cryar, A. and Williams, Mark A. and Gooptu, Bibekbrata and Thalassinos, Konstantinos
(2018)
Deconvolution of ion mobility mass spectrometry arrival time distributions using a genetic algorithm approach: application to α1-antitrypsin peptide binding .
International Journal of Mass Spectrometry
426,
pp. 29-37.
ISSN 1387-3806.
Redzej, Adam and Ukleja, Marta and Connery, Sarah and Trokter, Martina and Felisberto‐Rodrigues, Catarina and Cryar, A. and Thalassinos, Konstantinos and Hayward, Richard D. and Orlova, Elena V. and Waksman, Gabriel
(2017)
Structure of a VirD4 coupling protein bound to a VirB type IV secretion machinery .
The EMBO Journal
36
(19),
pp. e201796629.
ISSN 0261-4189.
Willhoft, Oliver and Kerr, R. and Patel, Dipali and Zhang, Wenjuan and Al-Jassar, Caezar and Daviter, Tina and Millson, S. and Thalassinos, Konstantinos and Vaughan, Cara K.
(2017)
The crystal structure of the Sgt1-Skp1 complex: the link between Hsp90 and both SCF E3 ubiquitin ligases and kinetochores .
Scientific Reports
pp. 41626.
ISSN 2045-2322.
Osborne, Andrew and Thalassinos, Konstantinos and Davies, Heledd
(2016)
Expansion of Lysine-rich repeats in Plasmodium proteins generates novel localisation sequences that target the periphery of the host Erythrocyte .
Journal of Biological Chemistry
291,
pp. 26188-26207.
ISSN 0021-9258.
Bullock, Joshua and Schwab, J. and Thalassinos, Konstantinos and Topf, Maya
(2016)
The importance of non-accessible crosslinks and solvent accessible surface distance in modelling proteins with restraints from crosslinking mass spectrometry .
Molecular & Cellular Proteomics
15
(7),
pp. 2491-2500.
ISSN 1535-9476.
Harvey, D.J. and Scarff, C.A. and Edgeworth, M. and Struwe, W.B. and Pagel, K. and Thalassinos, Konstantinos and Crispin, M. and Scrivens, J.
(2016)
Travelling-wave ion mobility and negative ion fragmentation of high-mannoseN-glycans .
Journal of Mass Spectrometry
51
(3),
pp. 219-235.
ISSN 1076-5174.
Nyon, M.P. and Prentice, T. and Day, J. and Kirkpatrick, J. and Sivalingam, G.N. and Levy, G. and Haq, I. and Irving, J.A. and Lomas, D.A. and Christodoulou, John and Gooptu, Bibek and Thalassinos, Konstantinos
(2015)
An integrative approach combining ion mobility mass spectrometry, X-ray crystallography, and nuclear magnetic resonance spectroscopy to study the conformational dynamics of α1-antitrypsin upon ligand binding .
Protein Science
24
(8),
pp. 1301-1312.
ISSN 0961-8368.
Nyon, M.P. and Prentice, T. and Day, J. and Kirkpatrick, J. and Sivalingam, G.N. and Lévy, Géraldine R. and Haq, I. and Irving, J. and Lomas, D.A. and Christodoulou, John and Gooptu, Bibek and Thalassinos, Konstantinos
(2015)
An integrative approach combining ion mobility mass spectrometry, X-ray crystallography and NMR spectroscopy to study the conformational dynamics of α1-antitrypsin upon ligand binding .
Protein Science
24
(8),
pp. 1301-1312.
ISSN 0961-8368.
Quay, Doris H.X. and Cole, Ambrose R. and Cryar, A. and Thalassinos, Konstantinos and Williams, Mark A. and Bhakta, Sanjib and Keep, Nicholas H.
(2015)
Structure of the stationary phase survival protein YuiC
from B.subtilis .
BMC Structural Biology
15
(12),
ISSN 1472-6807.
Thalassinos, Konstantinos and Pandurangan, Arun and Xu, M. and Alber, F. and Topf, Maya
(2013)
Conformational states of macromolecular assemblies explored by integrative structure calculation .
Structure
21
(9),
pp. 1500-1508.
ISSN 0969-2126.
Sivalingam, G.N. and Yan, Jun and Sahota, Harpal and Thalassinos, Konstantinos
(2013)
Amphitrite: a program for processing travelling wave ion mobility mass spectrometry data .
International Journal of Mass Spectrometry
345,
pp. 54-62.
ISSN 1387-3806.
Tarr, Sarah J. and Cryar, Adam and Thalassinos, Konstantinos and Haldar, K. and Osborne, Andrew R.
(2013)
The C-terminal portion of the cleaved HT motif is necessary and sufficient to mediate export of proteins from the malaria parasite into its host cell .
Molecular Microbiology
87
(4),
pp. 835-850.
ISSN 0950-382X.
Chan, J.J. and Flatters, D. and Rodrigues-Lima, F. and Yan, J. and Thalassinos, Konstantinos and Katan, M.
(2013)
Comparative analysis of interactions of RASSF1-10 .
Advances in Biological Regulation
53
(2),
pp. 190-201.
ISSN 2212-4926.
Chauviac, Francois-Xavier and Bommer, M. and Yan, Jun and Parkin, G. and Daviter, Tina and Lowden, Philip A.S. and Raven, E. L. and Thalassinos, Konstantinos and Keep, Nicholas H.
(2012)
Crystal structure of reduced MsAcg a putative nitroreductase from Mycobacterium smegmatis, and a close homologue of Mycobacterium tuberculosis Acg .
Journal of Biological Chemistry
287,
pp. 44372-44383.
ISSN 0021-9258.
Patel, N.A. and Crombie, A. and Slade, S.E. and Thalassinos, Konstantinos and Hughes, C. and Connolly, J.B. and Langridge, J. and Murrell, J.C. and Scrivens, J.H.
(2012)
Comparison of one- and two-dimensional liquid chromatography approaches in the label-free quantitative analysis of methylocella silvestris .
Journal of Proteome Research
11
(9),
pp. 4755-4763.
ISSN 1535-3893.
Walldén, Karin and Williams, Robert and Yan, Jun and Lian, Pei W. and Wang, Luchun and Thalassinos, Konstantinos and Orlova, Elena and Waksman, Gabriel
(2012)
Structure of the VirB4 ATPase, alone and bound to the core complex of a type IV secretion system .
Proceedings of the National Academy of Sciences of the United States of America
109
(28),
pp. 11348-11353.
ISSN 0027-8424.
Nyon, Mun Peak and Segu, Lakshmi and Cabrita, L.D. and Lévy, Géraldine R. and Kirkpatrick, J. and Roussel, B.D. and Patschull, Anathe O.M. and Barrett, Tracey E. and Ekeowa, U.I. and Kerr, R. and Waudby, Christopher A. and Kalsheker, N. and Hill, M. and Thalassinos, Konstantinos and Lomas, D.A. and Christodoulou, John and Gooptu, Bibek
(2012)
Structural dynamics associated with intermediate formation in an archetypal conformational disease .
Structure
20
(3),
pp. 504-512.
ISSN 0969-2126.
Malet, Hélène and Canellas, F. and Sawa, J. and Yang, J. and Thalassinos, Konstantinos and Ehrmann, M. and Clausen, T. and Saibil, Helen R.
(2012)
Newly folded substrates inside the molecular cage of the HtrA chaperone DegQ .
Nature Structural & Molecular Biology
19,
pp. 152-157.
ISSN 1545-9993.
Thalassinos, Konstantinos and Vissers, J.P.C. and Tenzer, S. and Levin, Y. and Thompson, J.W. and Daniel, D. and Mann, D. and DeLong, M.R. and Moseley, M.A. and America, A.H. and Ottens, A.K. and Cavey, G.S. and Efstathiou, G. and Scrivens, J.H. and Langridge, J.I. and Geromanos, S.J.
(2012)
Design and application of a data-independent precursor and product ion repository .
Journal of The American Society for Mass Spectrometry
23
(10),
pp. 1808-1820.
ISSN 1044-0305.
Harvey, D.J. and Sobott, F. and Crispin, M. and Wrobel, A. and Bonomelli, C. and Vasiljevic, S. and Scanlan, C.N. and Scarff, C.A. and Thalassinos, Konstantinos and Scrivens, J.H.
(2011)
Ion mobility mass spectrometry for extracting spectra of N-glycans directly from incubation mixtures following glycan release: application to glycans from engineered glycoforms of intact, folded HIV gp120 .
Journal of The American Society for Mass Spectrometry
22
(3),
pp. 568-581.
ISSN 1044-0305.
Hilton, G.R. and Thalassinos, Konstantinos and Grabenauer, M. and Sanghera, N. and Slade, S.E. and Wyttenbach, T. and Robinson, P.J. and Pinheiro, T.J.T. and Bowers, M.T. and Scrivens, J.H.
(2010)
Structural analysis of prion proteins by means of drift cell and traveling wave ion mobility mass spectrometry .
Journal of The American Society for Mass Spectrometry
21
(5),
pp. 845-854.
ISSN 1044-0305.
Wyttenbach, T. and Grabenauer, M. and Thalassinos, Konstantinos and Scrivens, J.H. and Bowers, M.T.
(2010)
The effect of calcium ions and peptide ligands on the relative stabilities of the Calmodulin Dumbbell and compact structures .
The Journal of Physical Chemistry B
114
(1),
pp. 437-447.
ISSN 1520-6106.
Jackson, A.T. and Thalassinos, Konstantinos and John, R.O. and McGuire, N. and Freeman, D. and Scrivens, J.H.
(2010)
Characterisation of end groups in poly(2-hydroxyethyl methacrylate) by means of electrospray ionisation-mass spectrometry/mass spectrometry (ESI-MS/MS) .
Polymer
51
(6),
pp. 1418-1424.
ISSN 0032-3861.
Thalassinos, Konstantinos and Grabenauer, M. and Slade, S.E. and Hilton, G.R. and Bowers, M.T. and Scrivens, J.H.
(2009)
Characterization of phosphorylated peptides using traveling wave-based and drift cell ion mobility mass spectrometry .
Analytical Chemistry
81
(1),
pp. 248-254.
ISSN 0003-2700.
Leary, J.A. and Schenauer, M.R. and Stefanescu, R. and Andaya, A. and Ruotolo, B.T. and Robinson, C.V. and Thalassinos, Konstantinos and Scrivens, J.H. and Sokabe, M. and Hershey, J.W.B.
(2009)
Methodology for measuring conformation of solvent-disrupted protein subunits using T-WAVE ion mobility MS: an investigation into eukaryotic initiation factors .
Journal of the American Society for Mass Spectrometry
20
(9),
pp. 1699-1706.
ISSN 1044-0305.
Patel, V.J. and Thalassinos, Konstantinos and Slade, S.E. and Connolly, J.B. and Crombie, A. and Murrell, J.C. and Scrivens, J.H.
(2009)
A comparison of labeling and label-free Mass Spectrometry-based Proteomics approaches .
Journal of Proteome Research
8
(7),
pp. 3752-3759.
ISSN 1535-3893.
Scarff, C.A. and Patel, V.J. and Thalassinos, Konstantinos and Scrivens, J.H.
(2009)
Probing hemoglobin structure by means of traveling-wave ion mobility mass spectrometry .
Journal of the American Society for Mass Spectrometry
20
(4),
pp. 625-631.
ISSN 1044-0305.
Scarff, C.A. and Thalassinos, Konstantinos and Hilton, G.R. and Scrivens, J.H.
(2008)
Travelling wave ion mobility mass spectrometry studies of protein structure: biological significance and comparison with X-ray crystallography and nuclear magnetic resonance spectroscopy measurements .
Rapid Communications in Mass Spectrometry
22
(20),
pp. 3297-3304.
ISSN 0951-4198.
Clokie, M.R.J. and Thalassinos, Konstantinos and Boulanger, P. and Slade, S.E. and Stoilova-McPhie, S. and Cane, M. and Scrivens, J.H. and Mann, N.H.
(2008)
A proteomic approach to the identification of the major virion structural proteins of the marine cyanomyovirus S-PM2 .
Microbiology
154
(6),
pp. 1775-1782.
ISSN 1350-0872.
Hilton, G.R. and Jackson, A.T. and Thalassinos, Konstantinos and Scrivens, J.H.
(2008)
Structural analysis of synthetic polymer mixtures using ion mobility and tandem mass spectrometry .
Analytical Chemistry
80
(24),
pp. 9720-9725.
ISSN 0003-2700.
Jackson, A.T. and Slade, S.E. and Thalassinos, Konstantinos and Scrivens, J.H.
(2008)
End-group characterisation of poly(propylene glycol)s by means of electrospray ionisation–tandem mass spectrometry (ESI-MS/MS) .
Analytical and Bioanalytical Chemistry
392
(4),
pp. 643-650.
ISSN 1618-2642.
Book Section
Chang, Y.-P. and Mahadeva, R. and Patschull, A.O.M. and Nobeli, Irene and Ekeowa, U.I. and McKay, A.R. and Thalassinos, Konstantinos and Irving, J.A. and Haq, I. and Nyon, Mun Peak and Christodoulou, John and Ordóñez, A. and Miranda, E. and Gooptu, Bibek
(2011)
Targeting serpins in high-throughput and structure-based drug design .
In: Whisstock, J.C. and Bird, P.I. (eds.)
Serpin Structure and Evolution .
Methods In Enzymology.
New York, U.S.: Elsevier.
pp. 139-175.
ISSN 0076-6879.
ISBN 9780123859501.