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Dr Tracey Barrett

Senior Lecturer in Structural Biology

Contact details

email: t.barrett@mail.cryst.bbk.ac.uk
tel: +44 (0)20 7631 6822
fax: +44 (0)20 7631 6803

Research website


Awards and memberships

MRC Suffrage Science award for contributions to the Biological Sciences, 2012

Elected member of the Medical Research Club since 2010

 

Science Week 2016

[Birkbeck Blog] Dr Barrett was part of the discussion panel for the film screening and discussion around the film, Life Story: The Race for the Double- Helix (11 April 2016)


About Dr Tracey Barrett

Research interests

  • Kaposi’s sarcoma is the most common form of AIDs related cancer whose main causative agent is the Kaposi’s Sarcoma-Associated Herpes Virus (KSHV). KSHV infection is also responsible for multicentric Castleman’s disease and primary effusion lymphoma, an aggressive cancer for which there are currently no effective treatments. We seek to understand how KSHV subverts host cellular mechanisms to avoid immune detection and promote proliferation, both of which are central to its malignancy. Mechanisms 'hijacked' by KSHV include the canonical and alternative NF-κB pathways that have been directly linked to malignancy as well as those that function in RNA degradation. These pathways are aberrantly activated by virally encoded, host mimetic proteins and it is our aim to establish how interactions with their cellular targets lead to viral pathogenesis using an interdisciplinary approach to enable the dissection of key protein-protein, protein-nucleic acid complexes. In addition, we also have interests in DNA repair with ongoing projects in prokaryotic excision repair mechanisms, eukaryotic homologous recombination and replication

Selected publications

    • Briggs, L.C. and Chan, A.W.E. and Davis, C.A. and Whitelock, N. and Hotiana, H. and Baratchian, M. and Bagneris, Claire and Selwood, D. and Collins, M.K. and Barrett, Tracey (2017) IKKγ mimetic peptides block the resistance to apoptosis associated with KSHV infection. Journal of Virology 91 (23), e01170-17. ISSN 0022-538X.
    • Lee, Hyunah and Patschull, Anathe and Bagneris, Claire and Ryan, H. and Sanderson, C.M. and Ebrahimi, B. and Nobeli, Irene and Barrett, Tracey E. (2017) KSHV SOX mediated host shutoff: the molecular mechanism underlying mRNA transcript processing. Nucleic Acids Research 45 (8), pp. 4756-4767. ISSN 0305-1048.
    • Bagneris, Claire and Rogala, Kacper B. and Baratchian, M. and Zamfir, Vlad and Kunze, Micha B.A. and Dagless, S. and Pirker, K.F. and Collins, M.K. and Hall, B.A. and Barrett, Tracey E. and Kay, C.W.M. (2015) Probing the solution structure of IκB Kinase (IKK) Subunit γ and its interaction with Kaposi Sarcoma-associated Herpes Virus Flice-interacting protein and IKK Subunit β by EPR spectroscopy. Journal of Biological Chemistry 290 (27), pp. 16539-16549. ISSN 0021-9258.
    • Webster, Matthew P. and Jukes, R. and Zamfir, V.S. and Kay, Christopher W.M. and Bagneris, Claire and Barrett, Tracey E. (2012) Crystal structure of the UvrB dimer: insights into the nature and functioning of the UvrAB damage engagement and UvrB-DNA complexes. Nucleic Acids Research 40 (17), pp. 8743-8758. ISSN 0305-1048
    • Bagneris, Claire, Ageichik, A.V. and Cronin, Nora and Wallace, Bonnie A. and Collins, M. and Boshoff, C. and Waksman, Gabriel and Barrett, Tracey E. (2008) Crystal structure of a vFlip-IKKγ Complex: insights into viral activation of the IKK Signalosome. Molecular Cell 30 (5), pp. 620-631.

Teaching

A stapled peptide-KSHV vFLIP complex