Dept of Biological Sciences | Our staff | Academic staff | Professor Carolyn Moores
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Professor Carolyn Moores

Professor of Structural Biology

Contact details

email: c.moores@mail.cryst.bbk.ac.uk
tel: 020 7631 6858
fax: 020 7631 6803

 

About Professor Carolyn Moores

 

Research interests

The microtubule cytoskeleton is essential for many cellular processes including cell division, motility, definition of cell architecture and differentiation. Our research is focused on understanding microtubule organisation and dynamics, and how these are harnessed for the life and health of the cell. Microtubule regulation and organization by a plethora of proteins is adapted to different functional contexts. We use a combination of biochemistry, biophysics and structural biology by cryo-electron microscopy to elucidate the mechanisms by which kinesin motors and microtubule associated proteins interact with and regulate microtubules.

Professor Moores gave her inaugural lecture on June 1 2015: Microtubules and Microscopes: exploring the cytoskeleton [Birkbeck event blog]

Recent publications

Structural basis of human kinesin-8 function and inhibition.

Locke J, Joseph AP, Pena A, Mockel MM, Mayer TU, Moores CA*. PNAS 2017 In press.

A structural model for microtubule minus-end recognition and protection by CAMSAP proteins.

Atherton J, Jiang K, Stangier MM, Luo Y, Hua S, Houben K, van Hooff JJE, Joseph AP, Scarabelli G, Grant BJ, Roberts AJ, Topf M, Steinmetz MO, Baldus M, Moores CA*, Akhmanova A*. NSMB 2017 In press.

The divergent mitotic kinesin MKLP2 exhibits atypical structure and mechanochemistry.

Atherton J, Yu IM, Cook A, Muretta JM, Joseph A, Major J, Sourigues Y, Clause J, Topf M, Rosenfeld SS, Houdusse A*, Moores CA*.
Elife. 2017 Aug 11;6. pii: e27793. doi: 10.7554/eLife.27793.