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Professor Carolyn Moores

Professor of Structural Biology

Head of Department

Contact details

email: c.moores@mail.cryst.bbk.ac.uk
tel: 020 7631 6820
fax: 020 7631 6803

 

About Professor Carolyn Moores

 

Research interests

The cytoskeleton is essential for many cellular processes including cell division, motility, definition of cell architecture and differentiation. Our current research is focused on understanding microtubule organisation and dynamics, and how these are harnessed for the life and health of cells. Microtubule regulation and organization by a plethora of proteins is adapted to different functional contexts. We use a combination of biochemistry, biophysics and structural biology by cryo-electron microscopy to elucidate the mechanisms by which kinesin motors and microtubule associated proteins interact with and regulate microtubules.

Major funding from ERC Synergy Grant for ArpComplexity research: Birkbeck to jointly lead major research project into muscle development, function and disease [October 2018]

News story on Professor Moores' research: Birkbeck research project will provide new insight into the 'building blocks' of our brains [November 2017]

Recent papers

Pseudo-repeats in doublecortin make distinct mechanistic contributions to microtubule regulation. Manka, SW, Moores, CA (2019) https://www.biorxiv.org/content/10.1101/808899v1

Kinesin-8B controls basal body function and flagellum formation and is key to malaria transmission. (2019) Life Science Alliance doi: 10.26508/lsa.201900488. Zeeshan M, Ferguson DJ, Abel S, Burrrell A, Rea E, Brady D, Daniel E, Delves M, Vaughan S, Holder AA, Le Roch KG, Moores CA, Tewari R

Mitotic phosphorylation by NEK6 and NEK7 reduces the microtubule affinity of EML4 to promote chromosome congression. (2019) Science Signalling doi: 10.1126/scisignal.aaw2939. Adib R, Montgomery JM, Atherton J, O’Regan L, Richards MW, Straatman KR, Roth D, Straube A, Bayliss R, Moores CA, Fry AM

Cryo-EM structure of the Ustilago maydis kinesin-5 motor domain bound to microtubules. (2019). von Loeffelholz, O. Moores, CA. JSB, 207, 312-316

A microtubule RELION-based pipeline for cryo-EM image processing (2019). Alexander D Cook, Szymon W Manka, Su Wang, Carolyn Moores, Joseph Atherton. JSB In press.

Structural determinant of microtubule minus end preference in CAMSAP CKK domains. Atherton J, Luo Y, Xiang S, Yang C, Jiang K, Stangier M, Vemu A, Cook AD, Wang S, Roll-Mecak A, Steinmetz MO, Akhmanova A, Baldus M, Moores, CA. bioRxiv https://doi.org/10.1101/586230