Dr Carolyn Moores
Reader in Structural Biology
The microtubule cytoskeleton of cells is essential in many processes, including cell division, motility, control of cell architecture and differentiation. Our research in focused on understanding microtubule organisation, dynamics and the resulting roles that microtubules play in the life of the cell. Microtubule regulation and organization by a plethora of diverse proteins is adapted to different functional contexts. We use a combination of biochemistry, biophysics and structural biology by cryo-electron microscopy to elucidate the mechanisms by which kinesin motors and microtubule associated proteins interact with and regulate microtubules.
Goulet A, Behnke-Parks WM, Sindelar CV, Major J, Rosenfeld SS, Moores CA
J Biol Chem. 2012 Dec 28;287(53):44654-66.
Liu JS, Schubert CR, Fu X, Fourniol, FJ, Jaiswal JK, Houdusse A, Stultz CM, Moores CA, Walsh CA
Mol. Cell 2012 Sep 14;47(5):707-21.
Maurer SP, Fourniol FJ, Bohner G, Moores CA, Surrey T
Cell. 2012 Apr 13;149(2):371-82.
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