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Dr Anthony Roberts

  • Overview



    Anthony is a Wellcome Trust Senior Research Fellow within the Institute of Structural Molecular Biology at Birkbeck/UCL. Anthony’s research focuses on the action of ‘motor proteins’; specialised proteins that travel inside cells and help them organise their contents, move, divide and respond to signals. Following PhD studies in cryo-electron microscopy with Prof. Peter Knight and Dr. Stan Burgess at the University of Leeds, Anthony trained as a Sir Henry Wellcome Postdoctoral Fellow based in the single-molecule laboratory of Prof. Samara Reck-Peterson at Harvard Medical School. He started his own group at Birkbeck investigating microtubule-based transport in late 2014, supported by a Sir Henry Dale Fellowship. Now, Anthony’s group is using structural biology, cell biology, and single-molecule techniques to investigate the following questions: How do dynein and kinesin motor proteins generate force and movement? How are they regulated in living cells? How and why does their malfunction give rise to human diseases?

  • Research


    Research overview

    We are investigating the mechanisms by which molecules are spatially organized within living cells. A main focus is on dynein, a large but poorly understood motor protein that uses ATP hydrolysis to transport cellular components and signals along microtubules. The overarching goal of our research is to understand how dynein works as a force-generating machine, and how dynein molecules are regulated to bring about coherent cellular functions. We are also interested in how defects in the dynein machinery cause human disease, and how dynein operates with the other class of microtubule motor, kinesin. Core techniques in our research are cryo-electron microscopy, in vitro reconstitution, cell biology, and single-molecule fluorescence microscopy.

  • Supervision and teaching

    Supervision and teaching


    Doctoral alumni since 2013-14

  • Publications


    External Repositories