Prof Nicholas Keep
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Overview
Overview
Extended absence from the college
I do not work Mondays
Qualifications
- PhD, University of Cambridge, 1993
- MA, University of Cambridge, 1992
Professional activities
Member of British Crystallographic Association (former Treasurer of Biological Structures Group)
Member of the Acid Fast Club
ORCID
0000-0002-5042-1837 -
Research
Research
Research interests
- Structures of Proteins of Mycobacteria (Tuberculosis) particularly dormancy
- Structures of proteins involved in muscular dystrophys
- X-ray crystallography of proteins
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Supervision and teaching
Supervision and teaching
Supervision
Doctoral alumni since 2013-14
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REBECCA RODDAN
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JENNIFER PRITCHARD
Teaching
Teaching modules
- Protein Expression, Purification and Biophysical Characterisation (SCBS058S7)
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Publications
Publications
Article
- Roddan, R. and Subrizi, F. and Broomfield, J. and Ward, J.M. and Keep, Nick and Hailes, H.C. (2021) Chemoenzymatic cascades toward Methylated Tetrahydroprotoberberine and Protoberberine Alkaloids. Organic Letters 23 (16), pp. 6342-6347. ISSN 1523-7060.
- Maitra, Arundhati and Nukala, Syamasundari and Dickman, R. and Martin, Liam T. and Munshi, Tulika and Gupta, Antima and Shepherd, Adrian J. and Arnvig, K.B. and Tabor, A.B. and Keep, Nicholas H. and Bhakta, Sanjib (2021) Characterization of the MurT/GatD complex in Mycobacterium tuberculosis towards validating a novel anti-tubercular drug target. JAC-Antimicrobial Resistance 3 (1), ISSN 2632-1823.
- Roddan, Rebecca and Keep, Nicholas H. and Sula, Altin (2020) Single step syntheses of (1 S)-aryltetrahydroisoquinolines by norcoclaurine synthases. Nature Communications 3 (170), ISSN 2041-1723.
- Roddan, R. and Ward, J.M. and Keep, Nicholas H. and Hailes, H.C. (2020) Pictet-Spenglerases in Alkaloid Biosynthesis: future applications in Biocatalysis. Current Opinion in Chemical Biology 55, pp. 69-76. ISSN 1367-5931.
- Ziveri, J. and Chhuon, C. and Jamet, A. and Rytter, H. and Prigent, G. and Tros, F. and Barel, M. and Coureuil, M. and Lays, C. and Henry, T. and Keep, Nicholas H. and Guerrera, I.C. and Charbit, A. (2019) Critical role of a sheath phosphorylation site on the assembly and function of an atypical type VI secretion system. Molecular and Cellular Proteomics 18 (12), pp. 2418-2432. ISSN 1535-9476.
- Roddan, Rebecca and Gygli, G. and Sula, Altin and Méndez-Sánchez, D. and Pleiss, J. and Ward, J.M. and Keep, Nicholas H. and Hailes, H.C. (2019) The acceptance and kinetic resolution of alpha-Methyl Substituted Aldehydes by Norcoclaurine Synthase. ACS Catalysis 9 (10), pp. 9640-9649. ISSN 2155-5435.
- Maitra, Arundhati and Munshi, Tulika and Healy, J. and Martin, L.T. and Vollmer, W. and Keep, Nicholas H. and Bhakta, Sanjib (2019) Cell wall peptidoglycan in Mycobacterium Tuberculosis: an Achilles’ heel for the TB-causing pathogen. FEMS Microbiology Reviews 43 (5), pp. 548-575. ISSN 1574-6976.
- Clark, Alice and Egberts, W.V. and Kondrat, F.D.L. and Hilton, G.R. and Ray, N.J. and Cole, Ambrose and Carver, J.A. and Benesch, J.L.P. and Keep, Nicholas H. and Boelens, W.C. and Slingsby, Christine (2018) Terminal regions confer plasticity to the tetrameric assembly of human HspB2 and HspB3. Journal of Molecular Biology 430 (18B), pp. 3297-3310. ISSN 0022-2836.
- Quay, D.H.X. and Qureshi, A. and Bhakta, Sanjib and Keep, Nicholas H. (2018) Mutation studies of the Gene Encoding YuiC, a Stationary Phase Survival Protein in Bacillus subtilis. Malaysian Journal of Microbiology 14 (2), ISSN 2231-7538.
- Keep, Nicholas H. and Sula, Altin (2017) Structural evidence for the dopamine-first mechanism of norcoclaurine synthase. Biochemistry 56 (40), pp. 5274-5277. ISSN 0006-2960.
- Northey, Thomas and Venthur, H. and De Biasio, F. and Chauviac, Francois-Xavier and Cole, Ambrose and Lisboa Ribeiro Junior, K.A. and Grossi, G. and Falabella, P. and Field, L.M. and Keep, Nicholas H. and Zhou, J.J. (2016) Crystal structures and binding dynamics of Odorant-Binding Protein 3 from two aphid species Megoura viciae and Nasonovia ribisnigri. Scientific Reports 6, pp. 24739. ISSN 2045-2322.
- Densham, R. and Garvin, A. and Keep, Nicholas H. and Watts, F. and Morris, J. and Et, al (2016) Human BRCA1-BARD1 Ubiquitin ligase activity counters chromatin barriers to DNA resection. Nature Structural & Molecular Biology 23, pp. 647-655. ISSN 1545-9993.
External Repositories