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Dr Renos Savva

Senior Research Fellow in Structural Molecular Biology
Academic Head, Rosalind Franklin Laboratory

Contact details

tel: 020 7631 6805 Direct + voicemail
tel: 020 7631 6868 Laboratory
email: r.savva@mail.cryst.bbk.ac.uk

Room G63d, Department of Biological Sciences, Malet Street, London WC1E 7HX

Research website

About Dr Renos Savva

Research interests

  • Viral proteins that interact with nucleotides and nucleic acids are important in a number of respects. They provide a means for the virus to subvert the cellular environment in the host, thus ensuring optimal conditions for replication. Replication of the virus is absolutely dependent on such proteins and they are often smaller and less complicated in terms of their subunit composition than cellular analogues. From a structural biologist’s point of view, they are ideal material to study the structural basis of fundamental enzymatic processes. Due to the innate physical differences between viral and host cell enzymes of similar function and their key role in viral propagation, they also provide an obvious target for the rational design of antiviral therapies.

    The group works on the nucleotide and nucleic acid binding and modification proteins of human Herpes viruses and T-type bacteriophages, with the aim of studying the fundamental link between structure and function.

    We also work on improving recombinant protein expression in E.coli using a combination of bioinformatic and experimental methods.

Recent publications