Dr Renos Savva
Senior Research Fellow in Structural Molecular Biology
Academic Head, Rosalind Franklin Laboratory
tel: 020 7631 6805 Direct + voicemail
tel: 020 7631 6868 Laboratory
Room G63d, Department of Biological Sciences, Malet Street, London WC1E 7HX
About Dr Renos Savva
Viral proteins that interact with nucleotides and nucleic acids are important in a number of respects. They provide a means for the virus to subvert the cellular environment in the host, thus ensuring optimal conditions for replication. Replication of the virus is absolutely dependent on such proteins and they are often smaller and less complicated in terms of their subunit composition than cellular analogues. From a structural biologist’s point of view, they are ideal material to study the structural basis of fundamental enzymatic processes. Due to the innate physical differences between viral and host cell enzymes of similar function and their key role in viral propagation, they also provide an obvious target for the rational design of antiviral therapies.
The group works on the nucleotide and nucleic acid binding and modification proteins of human Herpes viruses and T-type bacteriophages, with the aim of studying the fundamental link between structure and function.
We also work on improving recombinant protein expression in E.coli using a combination of bioinformatic and experimental methods.
Cole, Ambrose R. and Ofer, Sapir and Ryzhenkova, Ksenia and Baltulionis, Gediminas and Hornyak, Peter and Savva, Renos (2013) Architecturally diverse proteins converge on an analogous mechanism to inactivate Uracil-DNA glycosylase. Nucleic Acids Research 41 (18), pp. 8760-8775. ISSN 0305-1048.
Fogl, C. and Puckey, Loretto and Hinssen, U. and Zaleska, M. and el-Mezgueldi, M. and Croasdale, R. and Bowman, A. and Matsukawa, A. and Samani, N.J. and Savva, Renos and Pfuhl, M. (2012) A structural and functional dissection of the cardiac stress response factor MS1. Proteins: Structure, Function, and Bioinformatics 80 (2), pp. 398-409. ISSN 0887-3585.
Meier, C. and Brookings, D.C. and Ceska, T.A. and Doyle, C. and Gong, H. and McMillan, D. and Saville, G.P. and Mushtaq, A. and Knight, D. and Reich, S. and Pearl, L.H. and Powell, K.A. and Savva, Renos and Allen, R.A. (2012) Engineering human MEK-1 for structural studies: a case study of combinatorial domain hunting. Journal of Structural Biology 177 (2), pp. 329-334. ISSN 1047-8477.
Bagneris, Claire and Briggs, Louise C. and Savva, Renos and Ebrahimi, B. and Barrett, Tracey E. (2011) Crystal structure of a KSHV-SOX-DNA complex: insights into the molecular mechanisms underlying DNase activity and host shutoff. Nucleic Acids Research 39 (13), pp. 5744-5756. ISSN 0305-1048.
Maclagan, K. and Tommasi, R. and Laurine, E. and Prodromou, C. and Driscoll, P.C. and Pearl, L.H. and Reich, S. and Savva, Renos (2011) A combinatorial method to enable detailed investigation of protein-protein interactions. Future Medicinal Chemistry 3 (3), pp. 271-282. ISSN 1756-8919.