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Research interests

The Saibil group studies the operation of macromolecular machines using three-dimensional electron microscopy.
Our research projects are in the areas of molecular chaperones and assisted protein folding/unfolding, misfolding into amyloid, and protein refolding in membrane pore formation. We use single particle cryo-electron microscopy and electron tomography to study isolated complexes, irregular assemblies and cell sections.

Current projects

Molecular chaperones

Amyloid fibrils

Pore-forming toxins

Highlighted publication

A nanomachine for getting proteins into working shape

Chaperonin complex