Publications
2012
EBs Recognize a Nucleotide-Dependent Structural Cap at Growing Microtubule Ends. Maurer SP, Fourniol FJ, Bohner G, Moores CA, Surrey T. Cell 2012 149:371-382
See commentary on this research on the ISMB website
See commentary on this research on the LRI website
2011
Loop L5 acts as a conformational latch in the mitotic kinesin Eg5. Behnke-Parks WM, Vendome J, Honig B, Maliga Z, Moores C, Rosenfeld SS. J Biol Chem 2011 286: 5242-5253
Snapshots of kinesin motors on microtubule tracks. Fourniol FJ, Moores CA. Methods Mol Biol 2011. 778: 57-70
2010
Template-free 13-protofilament microtubule-MAP assembly visualized at 8Å
resolution. Fourniol FJ, Sindelar CV, Amigues B, Clare DK, Perderiset M, Francis F, Houdusse A, Moores CA. J Cell Biol. 2010 191:463-470
Highlight in The Journal of Cell Biology
N&V on PSI Nature Structural Biology Knowledgebase
Insight into the molecular mechanism of the multi-tasking kinesin-8 motor. Peters C, Brejc K, Belmont L, Bodey A, Lee Y, Yu M, Guo J, Sakowicz R, Hartman J, Moores CA. EMBO J. 2010 29:3437-3447
Kinesin-5 mitotic motors: Is loop5 the on/off switch? Moores CA. Cell Cycle 2010 9:1234
2009
9-Angstrom structure of a microtubule-bound mitotic motor. Bodey AJ, Kikkawa M, Moores CA. J Mol Biol. 2009 May 1;388(2):218-24
A new model for binding of kinesin 13 to curved microtubule protofilaments. Mulder AM, Glavis-Bloom A, Moores CA, Wagenbach M, Carragher B, Wordeman L, Milligan RA. J Cell Biol. 2009 Apr 6;185(1):51-7.
2008
Visualisation of a kinesin-13 motor on microtubule end mimics. Moores CA, Milligan, RA.
J. Mol Biol. Mar 28;377(3):647-54.
Studying microtubules by electron microscopy in "Introduction to Electron Microscopy for Biologists" (ed. T.D. Allen). Academic Press, Elsevier, Inc. Moores C.A. Methods Cell Biol. 2008;88:299-317. Review.
Implications for kinetochore-microtubule attachment from the structure of an engineered Ndc80 complex. Ciferri C, Pasqualato S, Screpanti E, Varetti G, Santaguida S, Dos Reis G, Maiolica A, Polka J, De Luca JG, De Wulf P, Salek M, Rappsilber J, Moores CA, Salmon ED, Musacchio A. Cell. 2008 May 2;133(3):427-39.
2006
Distinct roles of doublecortin modulating the microtubule cytoskeleton. Moores CA, Perderiset M, Kappeler C, Kain S, Drummond D, Perkins SJ, Chelly J, Cross R, Houdusse A, Francis F. EMBO J. 2006 Oct 4;25(19):4448-57.
The role of the kinesin-13 neck in microtubule depolymerization. Moores CA, Cooper J, Wagenbach M, Ovechkina Y, Wordeman L, Milligan RA. Cell Cycle. 2006 Aug;5(16):1812-5.
Lucky 13-microtubule depolymerisation by kinesin-13 motors. Moores CA, Milligan RA. J Cell Sci. 2006 Oct 1;119(Pt 19):3905-13.
2004
Mechanism of microtubule stabilization by doublecortin. Moores CA, Perderiset M, Francis F, Chelly J, Houdusse A, Milligan RA. Mol Cell. 2004 Jun 18;14(6):833-9.
Structure of a kinesin microtubule depolymerization machine. Shipley K, Hekmat-Nejad M, Turner J, Moores C, Anderson R, Milligan R, Sakowicz R, Fletterick R. EMBO J. 2004 Apr 7;23(7):1422-32.
2003
Regulation of KinI kinesin ATPase activity by binding to the microtubule lattice. Moores CA, Hekmat-Nejad M, Sakowicz R, Milligan RA. J Cell Biol. 2003 Dec 8;163(5):963-71.
A double-take on MAPs. Moores CA, Francis F, Perderiset M, Houdusse A. Nat Struct Biol. 2003 May;10(5):314-6.
An atomic model for actin binding by the CH domains and spectrin-repeat modules of utrophin and dystrophin. Sutherland-Smith AJ, Moores CA, Norwood FL, Hatch V, Craig R, Kendrick-Jones J, Lehman W. J Mol Biol. 2003 May 23;329(1):15-33.
2002
A mechanism for microtubule depolymerization by KinI kinesins. Moores CA, Yu M, Guo J, Beraud C, Sakowicz R, Milligan RA. Mol Cell. 2002 Apr;9(4):903-9.
2000
Structure of the utrophin actin-binding domain bound to F-actin reveals binding by an induced fit mechanism. Moores CA, Keep NH, Kendrick-Jones J. J Mol Biol 2000 Mar 24;297(2):465-80
Biochemical chacterization of the actin-binding properties of utrophin Moores CA, Kendrick-Jones J. Cell Motil Cytoskeleton 2000 Jun;46(2):116-28
1999
The 2.0A structure of the second calponin homology domain from the actin-binding region of the dystrophin homologue utrophin. Keep NH, Norwood FL, Moores CA, Winder SJ, Kendrick-Jones J. J Mol Biol 1999 Jan 22;285(3):1257-64
Dystrophin/Utrophin Moores CA and Kendrick-Jones J In "Guidebook to the Cytoskeletal and Motor proteins" 2nd edition (eds. T. Kreis and R. Vale). Oxford University Press, Oxford (1999).
Crystal structure of the actin-binding region of utrophin reveals a head-to-tail dimer. Keep NH, Winder SJ, Moores CA, Walke S, Norwood FL, Kendrick-Jones J. Structure Fold Des 1999 Dec 15;7(12):1539-46.
