Dr Anthony Roberts
Sir Henry Dale Fellow and Principal Investigator
tel: +44 (0)20 7631 6832
Room B60 (Office) and B54 (Lab), Department of Biological Sciences, Birkbeck, Malet Street, London, WC1E 7HX
Research website: www.roberts-lab.com
The short video profiles Dr Roberts on a typical working day and his research into walking molecules.
Dr Roberts gave a talk at Science Week 2016: Walking molecules:marching to a mechanism for biological movement [blog]
- We are investigating the mechanisms by which molecules are spatially organized within living cells. A main focus is on dynein, a large but poorly understood motor protein that uses ATP hydrolysis to transport cellular components and signals along microtubules. The overarching goal of our research is to understand how dynein works as a force-generating machine, and how dynein molecules are regulated to bring about coherent cellular functions. An additional interest is how defects in the dynein machinery cause human neurological disorders. Core techniques in our research are molecular electron microscopy, protein engineering, and single-molecule fluorescence microscopy.
- Selected research articles
Roberts AJ*, Goodman BS, Reck-Peterson SL*. (2014) Reconstitution of dynein transport to the microtubule plus end by kinesin. eLIFE. 3:e02641
Huang J*, Roberts AJ*, Leschziner AE, Reck-Peterson SL. (2012) Lis1 acts as a "clutch" between the ATPase and microtubule-binding domains of the dynein motor. Cell 150(5):975-86.
Feature by Martina Trokter & Thomas Surrey
Roberts AJ, Numata N, Walker ML, Kato YS, Malkova B, Kon T, Ohkura R, Arisaka F, Knight PJ, Sutoh K, Burgess SA. (2009) AAA+ Ring and linker swing mechanism in the dynein motor. Cell 136(3):485-95.
Feature by Andrew Carter & Anne Houdusse
Research highlight by BiopolymersReview article
Roberts AJ*, Kon T, Knight PJ, Sutoh K, Burgess SA*. (2013) Functions and mechanics of dynein motor proteins. Nature Reviews Molecular Cell Biology. 14:713-726.
- We are always looking for talented students to join the lab. Prospective graduate students should apply through the ISMB’s PhD programs and are welcome to email Anthony to discuss projects.