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Principles and practice in Structural Biology

For MRes and PhD students

X-ray crystallograpy, cryoEM, spectroscopies and biophysical characterisations

This lecture course on structural biology is especially for MRes and PhD students. MRes Structural Biology students and first year full-time PhD students should attend, and all other members of the Department are also invited.

Sessions take place on Thursdays and include discussion and question sessions, as well as practicals with equipment and computer software.

The course is organised by Dr Tracey Barrett

2017/18 timetable

All sessions take place on Thursdays from 11:00 - 13:00 unless otherwise stated.

Rooms are in the Malet Street (main building) unless otherwise stated.

Please note: Links to lecture handouts from 2016-17 have been removed. Links to the new lecture handouts will be added in the coming weeks.

(If you require copies of 2016-17 handouts, please email Mike Scopa.)

Autumn Term 2017

Date/time

Title/s

Speaker/s

Location

Thursday 12 October 2017
11:00 – 13:00

Protein expression and purification

Dr Claire Bagneris

B62/3

Thursday 19 October 2017
11:00 – 13:00

Diffraction theory, symmetry

Professor Helen Saibil and Professor Elena Orlova

GOR B13 Gordon Square

Thursday 26 October 2017

No lecture

No lecture

 

Tuesday 2 November 2017
11:00 – 13:00

Crystallisation, data collection and processing

Dr Ambrose Cole and Dr TC Tan

B62/3

Thursday 9 November 2017
11:00 – 13:00

Structure determination – Molecular replacement, experimental phasing

Dr Tracey Barrett and Dr Alan Cheung

B62/3

Thursday 16 November 2017
11:00 – 13:00

Refinement and model building

Professor Nicholas Keep and Dr Cara Vaughan

MAL 457

Thursday 23 November 2017
11:00 – 13:00

Sample preparation and data collection

Professor Carolyn Moores and Dr Natasha Lukoyanova

B62/3

Thursday 30 November 2017
11:00 – 13:00

Image formation, contrast, CTF

Professor Elena Orlova

B62/3

Thursday 7 December 2017
11:00 – 13:00

Alignment and classification; 3D reconstruction and validation

Professor Helen Saibil and Professor Elena Orlova

B62/3

Thursday 14 December 2017
11:00 – 13:00

Tomography of cells, organelles, unique complexes, correlative microscopy, soft X-ray tomography, sub-tomogram averaging

Dr Giulia Zanetti

B62/3

Spring Term 2018

Date

Title

Speaker(s)

Location

Thursday 11 January 2018
11:00 – 13:00

Characterisation of protein samples and complexes by light scattering and other methods.

Dr Tina Daviter

B62/3

Thursday 18 January 2018
11:00 – 13:00

Protein structure and interactions by NMR

Dr Mark Williams

B62/3

Thursday 25  January 2018
11:00 – 13:00

NMR: Protein dynamics

Dr Flemming Hansen

B62/3

Thursday 01 February 2018
11:00 – 13:00

Single molecule methods: TIRF, FRET, AFM and optical trapping

Dr Anthony Roberts

B62/3

Thursday 08 February 2018
11:00 – 13:00

Introduction to fluorescence and confocal microscopy; Super resolution optical microscopy

Dr Alan Lowe

B62/3

Thursday 15 February 2018

No lecture

No Lecture

Thursday 22 February 2018
11:00 – 13:00

Mass spectrometry

Dr Kostas Thalassinos

B62/3

Thursday 01 March 2018
11:00 – 13:00

Protein-protein docking, integrative modelling and model validation

Professor Maya Topf

B62/3

Thursday 08 March 2018
11:00 – 13:00

Chemoinformatics

Dr Irilenia Nobeli

B62/3

Thursday 15 March 2018
11:00 – 13:00

CD & IR spectroscopy

 

Professor Bonnie Wallace and Dr Amandine Marechal

B62/3